PD62-01 ALGINATE GEL COMBINED WITH POLYGLYCOLIC ACID IS A USEFUL NON-TUBULAR ARTIFICIAL NERVE SHEET IN A RAT ERECTILE DYSFUNCTION MODEL

You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology (PD62)1 Sep 2021PD62-01 ALGINATE GEL COMBINED WITH POLYGLYCOLIC ACID IS A USEFUL NON-TUBULAR ARTIFICIAL NERVE SHEET IN RAT ERECTILE DYSFUNCTION MODEL Shintaro Narita, Takashi Obara, Yoshihisa Suzuki, and Tomonori Habuchi NaritaShintaro Narita More articles by this author , ObaraTakashi Obara SuzukiYoshihisa Suzuki HabuchiTomonori View All Author Informationhttps://doi.org/10.1097/JU.0000000000002099.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Neuro-protection -regeneration cavernous nerve plexus biological/bioengineering solutions may a potential maintain erectile function. However, there are several limitations previous artificial materials, including need for device various diameters depending on the diameter be regenerated, inapplicability damaged sites that branched into Y-shape or type nerves, necessity suturing. Here we evaluated efficacy newly-developed sheet using freeze-dried alginate (ALG) with polyglycolic acid (PGA) mesh in rat model. METHODS: Bilateral nerves male rats were excised make an approximately 2 mm gap. piece sponge-like created covalent cross-linking ALG gel combined PGA was placed over gap cover each stump without any neural anastomosis (ALG group). We compared functions groups those sham group bilateral excision (excision group) (n=12, each). The function tested electric stimulation proximal portion mating behavior visually. Anatomical recovery tracer FluoroGold injection, followed visualization. RESULTS: had erection at 63 64 days, confirmed 10 (83.3%) 56 62 days. No observed group. Ten 12 erection, rates significantly higher than (p <0.01, p respectively). Using retrograde FluoroGold, rate positive pelvic ganglia 61 days (p=0.014). CONCLUSIONS: results our animal study demonstrated simply filling non-tubular sheets made restored after excision. This application patients who underwent radical prostatectomy sparing. Source Funding: None © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1072-e1072 Advertisement Copyright Permissions© Inc.MetricsAuthor Information Expand Loading ...